Female Patients with Androgenetic Alopecia: Immunohistochemical Picture of Scalp Biopsies

    September 2021 in “ Eureka: Health Sciences
    Olena Salyenkova
    TLDR Androgenetic alopecia in women may be improved by targeting oxidative stress, inflammation, and fibrosis.
    The study aimed to expand the understanding of immunohistochemical changes in female patients with androgenetic alopecia (AGA) by examining scalp biopsies from 30 female patients and comparing them to 20 control samples. The research identified several immunomorphological characteristics of AGA, including the presence of T-lymphocytes, macrophages, an imbalance of growth polypeptides, oxidative stress enzymes, and pathological collagen accumulation. These findings suggested that the pathological triad of "oxidative stress-microinflammation-fibrosis" and the imbalance of growth peptides could be potential targets for improving treatment standards for AGA.
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