Immunohistochemical Analysis of T-Cell Subsets in the Inflammatory Infiltrates of Alopecia Areata and Its Comparison with Androgenetic Alopecia

    April 2020 in “ International Journal of Dermatology ”
    Azadeh Rakhshan, Afshin Moradi, Hedieh Peiroolia
    TLDR T-cell patterns in skin help distinguish alopecia areata from androgenetic alopecia.
    This study conducted at Shohadae-Tajrish Hospital in 2018 compared T-cell subsets in the inflammatory infiltrates of alopecia areata (AA) and androgenetic alopecia (AGA) using immunohistochemical analysis. It involved 28 AA cases and 32 AGA cases. The results showed that peribulbar lymphocytic infiltration was significantly more common in AA patients (88.5%) compared to AGA patients (12.5%). Additionally, higher densities of CD3, CD4, and CD8+ T-cells were observed in various skin regions of AA patients, while CD3 and CD4+ T-cells around sebaceous ducts were more indicative of AGA. The study concluded that peribulbar lymphocytic infiltration and T-cell distribution in skin tissues are crucial for differentiating AA from AGA with high precision.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 1 year ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

    Related Research

    2 / 2 results