Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

    Pietro Gentile, John P. Cole, Megan A Cole, Simone Garcovich, Alessandra Bielli, Maria Giovanna Scioli, Augusto Orlandi, Chiara Insalaco, Valerio Cervelli
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    TLDR PRP treatment improves hair growth, and the device used can affect results, with some being more effective.
    The 2017 study assessed the efficacy of platelet-rich plasma (PRP) in treating androgenetic alopecia (AGA) using different protocols and collection systems. The first protocol involved 18 participants who received non-activated autologous PRP (A-PRP) on one half of their head and a placebo on the other half. Results showed significant improvement in hair count and density in the A-PRP treated area compared to the placebo. The second protocol involved 6 participants treated with calcium-activated PRP (AA-PRP) using two different collection devices, with the Regen device showing better hair density outcomes than the Arthrex device. A separate analysis of 18 male patients with mild to moderate male pattern hair loss (MPHL) treated with AA-PRP prepared with the Arthrex Angel System showed significant increases in hair density and follicular unit density. The study concluded that A-PRP treatment is effective in improving hair growth and density, and that different PRP collection devices can affect the outcomes of AA-PRP treatment, with the Arthrex system potentially being more effective due to higher levels of growth factors.
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