173 citations
,
August 2015 in “Developmental cell” This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.
56 citations
,
June 2015 in “Nature Protocols” This protocol describes using two-photon laser-scanning microscopy to study hair regeneration in live mice, offering detailed imaging capabilities for observing hair follicle stem cell behavior and manipulating cellular populations.
321 citations
,
March 2015 in “Nature” This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
426 citations
,
August 2014 in “Nature Medicine” This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.
173 citations
,
January 2014 in “Nature Cell Biology” This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.
394 citations
,
October 2013 in “Nature” 
265 citations
,
July 2012 in “Cell” This study found multipotent progenitors in sweat ducts that become unipotent after sweat gland development, highlighting distinct regenerative capabilities in adult glandular skin stem cell populations.
260 citations
,
June 2011 in “Cell” This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.
354 citations
,
February 2011 in “Genes & Development” This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
89 citations
,
August 2008 in “Human genetics” This study found that the EDAR 1540T/C genetic variant is significantly associated with hair thickness variation in Japanese populations, enhancing previously observed associations in Southeast Asian groups.
415 citations
,
January 2008 in “Cell” NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.
479 citations
,
January 2005 in “BioEssays” This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.
249 citations
,
May 2003 in “Developmental Biology” Ectodysplasin-A1 is crucial for developing hair, teeth, and glands.
990 citations
,
October 1999 in “Development” This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.
745 citations
,
February 1992 in “Trends in genetics” This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
