TLDR The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
The document from 2016 provides a comprehensive review of research on mammalian skin epidermis, particularly focusing on the role of stem cells in epidermal homeostasis, hair regeneration, and wound repair. It discusses the establishment and function of stem cells in skin development and adult tissue maintenance, as well as their response to injury. The document also explores the relationship between skin cancer and stem cell regulation, the process of terminal differentiation in the epidermis, and the importance of the extracellular matrix for epidermal stem cells. It highlights the genetic basis of glandular development, the cyclical regeneration of hair follicle stem cells, and the plasticity and regenerative capabilities of epithelial stem cells. The research emphasizes the complexity of signaling pathways, the influence of the stem cell niche, and the role of epigenetic mechanisms in governing cell identity. Despite progress in understanding skin biology, the document notes that many interactions between stem cells and their microenvironment remain unexplored, and new technologies are expected to advance future research.
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173 citations
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September 2015 in “Developmental cell” The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
56 citations
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July 2015 in “Nature Protocols” Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.
321 citations
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March 2015 in “Nature” Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
426 citations
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August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
173 citations
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January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
265 citations
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July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
89 citations
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August 2008 in “Human genetics” The EDAR gene greatly affects hair thickness in Asian populations.
479 citations
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January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
August 2022 in “Journal of Investigative Dermatology” Lef1 is essential for normal skin, hair growth, and healing wounds in mice.
December 2017 in “Chin J Cell Stem Cell (Electronic Edition)” Hair follicle stem cells help skin wounds heal faster.
January 2017 Dermal stem cells help regenerate hair follicles and heal skin wounds.
January 2008 in “Chinese bulletin of Life sciences”