The Efficacy and Safety of a Combination Cytopurine/Pentadecanoic Glyceride Topical Solution on Androgenetic Alopecia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

January 2007 in “ Journal of Clinical Dermatology ”

Chang Seop Hong, Tae Hee Han, Han K. Kang, Seung-Won An, Ji-Young Ahn, Seong Jun Seo

cytopurine pentadecanoic glyceride androgenetic alopecia topical solution phototrichogram anagen hair count AGA

Studysummary This study found that the new cytopurine/pentadecanoic glyceride topical solution significantly improved total hair count and reduced daily hair shedding in patients with androgenetic alopecia over 16 weeks, although other measures did not differ from placebo. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the efficacy of a new topical solution, cytopurine/pentadecanoic glyceride, for treating androgenetic alopecia (AGA) in a 16-week, double-blind, placebo-controlled trial involving 95 participants (74 men and 21 women). The treatment showed significant improvement in total hair count and daily shed hair count compared to baseline. However, there were no statistically significant differences between the treatment and placebo groups in anagen hair count, mean hair diameter, or subjective assessments of clinical improvement. The study confirmed the efficacy of the topical solution through objective phototrichogram assessments, although subjective measures and side effects did not differ significantly from the placebo.

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