Comparison of Effectiveness of Topical Tacrolimus and Betamethasone with Soft Paraffin in the Treatment of Patchy Alopecia Areata

    January 2009
    Azra Saleem, Moosa Khan, Ghulam Rasool Mashori, Azam Jah Samdani, Shujaath Asif, Jahanzeb Kazmi
    Image of study
    TLDR Betamethasone is more effective than Tacrolimus and soft paraffin for hair regrowth in patchy alopecia areata.
    In a study comparing the effectiveness of topical Tacrolimus, Betamethasone, and soft paraffin for treating patchy alopecia areata, 60 patients were divided into three groups of 20 each. They applied the treatments twice daily for 12 weeks. The primary outcome was hair regrowth rate, measured at weeks 4, 8, and 12. By week 12, the Betamethasone group showed a significantly higher hair regrowth score (3.5±0.11) compared to the Tacrolimus group (2.5±0.09) and the control group (0.5±0.05). Hair regrowth scores above 3 were observed in 70% of the Betamethasone group, 45% of the Tacrolimus group, and none in the control group. The study concluded that Betamethasone was more effective than Tacrolimus and soft paraffin in promoting hair regrowth in patients with mild to moderate patchy alopecia areata.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Is there any new drug that looks promising ?

      in Research/Science  24 upvotes 1 year ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community PYRILUTAMIDE KX-826 experience

      in Research/Science  100 upvotes 2 years ago
      A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  61 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Help! Minoxidil or Duta to avoid Shed of long hair.

      in Female  7 upvotes 9 months ago
      The user is considering using Tacrolimus Solution and topical Dutasteride to avoid shedding caused by Minoxidil, which they fear may lead to facial side effects. They are also concerned about scalp sensitivity and are exploring different treatment bases to manage seborrheic dermatitis.

      community I always hear the advice to reduce scalp inflammation. What are some non-steroidal ways to reduce inflammation?

      in Treatment  13 upvotes 1 week ago
      Non-steroidal ways to reduce scalp inflammation include using topical melatonin, urea shampoo, Zyrtec, turmeric with black pepper, omega-3 supplements, a self-made topical solution with cetirizine, melatonin, and piroctone olamine, ketoconazole shampoo, witch hazel shampoo, tacrolimus, and lifestyle changes like a healthy diet and regular exercise. Some users also mentioned unconventional methods like infrared light therapy and a carnivore diet.

      community Topical Dutasteride is Here.

      in Finasteride/Dutasteride  153 upvotes 4 years ago
      The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.

    Related Research

    13 / 13 results