Comparison of Effectiveness of Topical Tacrolimus and Betamethasone with Soft Paraffin in the Treatment of Patchy Alopecia Areata

    January 2009
    Azra Saleem, Moosa Khan, Ghulam Rasool Mashori, Azam Jah Samdani, Shujaath Asif, Jahanzeb Kazmi
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    TLDR Betamethasone is more effective than Tacrolimus and soft paraffin for hair regrowth in patchy alopecia areata.
    In a study comparing the effectiveness of topical Tacrolimus, Betamethasone, and soft paraffin for treating patchy alopecia areata, 60 patients were divided into three groups of 20 each. They applied the treatments twice daily for 12 weeks. The primary outcome was hair regrowth rate, measured at weeks 4, 8, and 12. By week 12, the Betamethasone group showed a significantly higher hair regrowth score (3.5±0.11) compared to the Tacrolimus group (2.5±0.09) and the control group (0.5±0.05). Hair regrowth scores above 3 were observed in 70% of the Betamethasone group, 45% of the Tacrolimus group, and none in the control group. The study concluded that Betamethasone was more effective than Tacrolimus and soft paraffin in promoting hair regrowth in patients with mild to moderate patchy alopecia areata.
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