Study of Therapeutic Comparison of Tacrolimus 0.1% and Minoxidil 2% in Alopecia Areata

    July 2013 in “ Our Dermatology Online ”
    Kallappa C. Herkal, S. R. Patil, Hosahalli Rjaiah Yogeesh, Raghu Mudigere Thimmappa, Lalitha Cholachaguddar
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    TLDR Minoxidil 2% is more effective than tacrolimus 0.1% for hair regrowth in mild to moderate patchy hair loss, and combining both might give better results.
    In a study conducted from December 2010 to November 2011, 75 patients with alopecia areata were treated with either tacrolimus 0.1% ointment or minoxidil 2% solution. By the end of the study, 69 patients had completed the treatment, with 35 in the minoxidil group and 34 in the tacrolimus group. The results showed that 65.71% of patients treated with minoxidil 2% had a regrowth score of 3 or more, compared to 44.12% of patients treated with tacrolimus 0.1%. The study concluded that minoxidil 2% was more effective in stimulating hair growth than tacrolimus 0.1% in treating mild to moderate patchy alopecia areata. Both treatments had minimal side effects, but the study suggested that a combination treatment might yield better results.
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