Evaluation of the Effect of Topical Calcipotriol Versus Platelet-Rich Plasma Versus a Combination of Both on Patients with Alopecia Areata

    November 2023 in “ Research Square (Research Square) ”
    Mahmoud Ali, Moustafa A. El Taieb, Ali Mohamed Younis Younis, Hassan Ibrahim, Mohamed Abdel-Latif, Nadia Ahmed, Firoz Ahmed, Eisa M. Hegazy
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    TLDR Combining calcipotriol and PRP is most effective for treating Alopecia Areata.
    In a double-blinded randomized clinical trial involving 39 patients with Alopecia Areata, the effects of topical calcipotriol, intra-lesion PRP, and their combination were compared. Group I received calcipotriol, Group II received PRP, and Group III received both treatments. All groups showed significant reductions in SALT scores and dermoscopic findings, with the combination treatment (Group III) showing the most substantial improvement, followed by PRP alone (Group II), and then calcipotriol alone (Group I). The study concluded that combining calcipotriol and PRP is particularly effective in reducing symptoms of Alopecia Areata.
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      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

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      in Treatment  1 upvotes 1 year ago
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