Differentiation of the Sebaceous Gland

The document reviewed the differentiation and morphogenesis of the sebaceous gland, emphasizing its role in skin barrier function and its relationship with hair follicles. It discussed the involvement of signaling pathways such as Wnt/β-catenin, Hedgehog, and c-myc in sebocyte proliferation and differentiation, and highlighted the significance of lipid metabolism, particularly stearoyl-CoA desaturase 1 (SCD1) and peroxisome proliferator-activated receptors (PPARs), in sebaceous gland function. Despite advancements in understanding these processes, the exact molecular mechanisms and their interactions remained unclear, necessitating further research to explore their contributions to skin diseases. The study used wholemounts of pilosebaceous units from mouse tail skin to illustrate these processes.