Reconnection Of Cysteine In Reduced Hair With Alkylene Dimaleates Via Thiol-Michael Click Chemistry

    January 2024 in “ International Journal of Cosmetic Science ”
    Yue Wu, Li Ma, Timson Chen, Kuan Chang, Jing Wang
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    TLDR A new method using 1,4-n-butylene dimaleate effectively repairs and strengthens damaged hair.
    The study investigates a novel method to reconnect reduced disulfide bonds in hair using thiol-Michael click chemistry with 1,4-n-butylene dimaleate. Virgin black Chinese hair was reduced with 8% thioglycolic acid and treated with the Michael reagent. Raman and FT-IR spectroscopy confirmed chemical changes, while tensile testing and DSC assessed mechanical and thermal properties. Results showed that 1,4-n-butylene dimaleate significantly improved hair's mechanical strength by restoring α-helix structures and forming new C-S bonds, compensating for broken disulfide bonds. Similar Michael reagents also enhanced the mechanical properties of reduced hair, suggesting this method effectively restores hair keratin's secondary conformation and strength.
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