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research Reconnection of cysteine in reduced hair with alkylene dimaleates via thiol‐Michael click chemistry

January 2024 in “International Journal of Cosmetic Science”

This study found that 1,4-n-butylene dimaleate can restore the mechanical properties of reduced hair by reconnecting disulfide bonds and improving the hair's structural integrity using a thiol-Michael click reaction, compared to untreated reduced hair.

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.

research A Comparative Study between the Efficacy and Safety of 5% Minoxidil Solution and 5% Minoxidil Milky Lotion in the Treatment of Male Androgenic Alopecia.

January 2017 in “PubMed”

This study observed that 5% minoxidil milky lotion increased hair density more than the standard solution at 8 weeks in males with androgenetic alopecia, but their efficacy was similar at later visits.

research The effect of Gyungokgo-gamibang extract on hair growth and protein expression in mice

5 citations , January 2011

This study found that Gyungohkgo-gamibang extract and minoxidil both significantly stimulated hair growth and increased hair density and thickness in C57BL/6 mice compared to a vehicle treatment.

research Hair Growth-Promoting Effects of a Multi-Targeted Cosmetic Formulation Containing PYGL, DP2, and 15-PGDH Inhibitors Developed Using AI-Based DeepZema® in Androgenetic Alopecia: A 24-Week Randomized Controlled Trial

April 2026 in “Cosmetics”

In this randomized, double-blind, placebo-controlled trial, researchers found that a multi-targeted cosmetic formulation containing TrinogeniX™ significantly increased hair density and thickness in individuals with androgenetic alopecia without adverse effects, suggesting it as a potential safe and effective treatment option.

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community 14 months on Fin, Total T 899, serum DHT 276 — high total T may still drive scalp DHT even when blood levels look controlled

3 upvotes 4 months ago

A 23-year-old male has been using finasteride and topical minoxidil for 14 months with slight improvement, but recent shedding led him to switch to a new minoxidil formulation without success. He is considering using topical RU58841 or dutasteride to better address scalp DHT, as his bloodwork shows high total testosterone and mid-range DHT levels.

community 8 months on 1/4 piece tablet Finasteride and 4 months on minoxidil

in Progress Pictures 379 upvotes 1 year ago

The user experienced significant hair regrowth using 0.25mg finasteride and topical minoxidil, with no side effects reported. They went from Norwood 4.5 to Norwood 2.5 in eight months.

community New update. 16 months on finasteride, 25 year old, 1.25mg daily. The first picture is a screenshot from a video taken in February 2023, hence the quality is kinda poor.

in Progress Pictures 418 upvotes 2 years ago

A 25-year-old user shared progress pictures after 16 months of using 1.25mg daily finasteride for hair loss, reporting noticeable results around months 4-5 and some initial side effects that resolved. The user experienced thickening and slight regrowth of the hairline.

community Is this regrowth? Finasteride for 7 months

7 upvotes 1 month ago

A 21-year-old experiencing hair loss since age 14 is using finasteride for 7 months and considering adding minoxidil and microneedling. They are contemplating switching to dutasteride in the future to manage DHT sensitivity and maintain current hair levels.

community 5 months on Fin 1 mg + biotin collagen daily supplement I think this is progress but idk and pls help me get more

5 upvotes 6 months ago

The user has been using 1mg finasteride and biotin-collagen supplements for 5 months, noticing some progress in hair regrowth. They also use various oils and shampoos, plan to start oral minoxidil, and seek advice on improving their hair care routine.

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Hair Loss Specialist
Ayodeji Temilade
London, England, United Kingdom

Ayodeji Temilade