Cx43 Hemichannel-Mediated Paracrine Involves in the Promotion of MSCs on Skin Wound Healing
December 2025
in “
Stem Cell Research & Therapy
”
Studysummary The researchers reported that mesenchymal stem cells promote wound healing by using Cx43 hemichannels to mediate ATP secretion, which supports macrophage polarization, angiogenesis, and fibroblast migration, suggesting a potential therapeutic strategy for improving tissue repair.
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The study identifies a novel mechanism by which mesenchymal stem cells (MSCs) promote wound healing through Cx43 hemichannel-mediated paracrine signaling, primarily involving ATP secretion. This process enhances macrophage polarization, angiogenesis, and fibroblast migration, leading to improved tissue repair. The findings highlight a new role for Cx43 hemichannels in MSC-facilitated tissue repair and suggest a promising therapeutic strategy for clinical applications to enhance wound healing.
