TLDR Mesenchymal stem cells help heal wounds by using Cx43 hemichannels to improve tissue repair.
The study identifies a novel mechanism by which mesenchymal stem cells (MSCs) promote wound healing through Cx43 hemichannel-mediated paracrine signaling, primarily involving ATP secretion. This process enhances macrophage polarization, angiogenesis, and fibroblast migration, leading to improved tissue repair. The findings highlight a new role for Cx43 hemichannels in MSC-facilitated tissue repair and suggest a promising therapeutic strategy for clinical applications to enhance wound healing.
July 2023 in “Bioengineering & translational medicine” Mesenchymal stem cell proteins in a special gel improved healing of severe burns.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
32 citations
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November 2016 in “Journal of Dental Research” Pannexin 3 is important for bone formation and the development of bone cells.
13 citations
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January 2021 in “Scientific Reports” Pannexin 3 helps skin and hair growth by controlling a protein called Epiprofin.
8 citations
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May 2024 in “PLoS Biology” Gap junctions help control feather pattern formation in chickens.
26 citations
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July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.
16 citations
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July 2008 in “BMC Genomics” Alpha 6 + /MHCI - cells have stem cell traits and are similar to mouse hair follicle stem cells.
