Determination of Cortisone and Cortisol in Human Scalp Hair Using an Improved LC-MS/MS-Based Method

    July 2023 in “ Clinical Chemistry and Laboratory Medicine (CCLM) ”
    Mina Mirzaian, Sofie K M van Zundert, Wim F. Schilleman … Sjoerd A.A. van den Berg
    Studysummary In this study, researchers developed an LC-MS/MS method to accurately quantify cortisone and cortisol levels in human scalp hair, finding that concentrations decrease predictably along the hair shaft, which could assist in identifying abnormal glucocorticoid exposure.
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    Research cited in this study 8

    1. A Quantitative Ultra-Performance Liquid Chromatography High-Resolution Mass Spectrometry Analysis of Steroids from Human Scalp Hair Journal of pharmaceutical and biomedical analysis · 2022
    2. Simultaneous LC-MS/MS Quantification of Glucocorticoids, Melatonin, and Its Metabolites in Hair Journal of Chromatography B · 2022
    3. Cross-Sectional Relation of Long-Term Glucocorticoids in Hair With Anthropometric Measurements and Their Possible Determinants: A Systematic Review and Meta-Analysis Obesity Reviews · 2021
    4. The Use of Hair Cortisol for the Assessment of Stress in Animals General and Comparative Endocrinology · 2018
    5. Determinants of Hair Cortisol and Hair Cortisone Concentrations in Adults Psychoneuroendocrinology · 2015
    6. LC-MS/MS-Based Method for Long-Term Steroid Profiling in Human Scalp Hair Clinical Endocrinology · 2015
    7. Validation and Reference Ranges of Hair Cortisol Measurement in Healthy Children Hormone Research in Paediatrics · 2014
    8. Correlation of Cortisol in 1-Cm Hair Segment with Salivary Cortisol in Humans: Hair Cortisol as an Endogenous Biomarker Clinical Chemistry and Laboratory Medicine (CCLM) · 2011