Correlation of Cortisol in 1-Cm Hair Segment with Salivary Cortisol in Humans: Hair Cortisol as an Endogenous Biomarker

    Qiaozhen Xie, Wei Gao, Jifeng Li, Ting Qiao, Jing Jin, Huihua Deng, Zuhong Lu
    TLDR Hair cortisol levels can reflect salivary cortisol levels in humans.
    The study validated the direct correlation between cortisol levels in 1-cm hair segments and salivary cortisol in healthy humans. Researchers collected saliva samples at three different times and hair samples 4 weeks later, measuring cortisol levels using high performance liquid chromatography tandem mass spectrometry. Significant correlations were found between salivary cortisol at different times and between hair cortisol and salivary cortisol at Time 2 and the average salivary cortisol. The results confirmed that blood-related diffusion is a biologically endogenous source of hair cortisol.
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