Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells
November 2023
in “Experimental Dermatology”
TLDR Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.
The research investigated the anti-ageing effect of exosomes derived from Dermal Sheath Cup Cells (ExoDSCCs) on Dermal Papilla Cells (DPCs), which undergo premature ageing in androgenetic alopecia and senescent alopecia. The study found that ExoDSCCs promote the proliferation, viability, and migration of senescent DPCs while inhibiting cell apoptosis. The expression of the senescence marker SA-β-Gal was significantly downregulated in senescent DPCs treated with ExoDSCCs. Additionally, ExoDSCCs activated the Wnt/β-catenin signalling in vitro and significantly promoted hair follicle reconstruction in senescent DPCs. The findings suggest that ExoDSCCs may restore the biological functions and improve the hair follicle induction ability of senescent DPCs, potentially offering a new strategy for intervening in the ageing process of DPCs and preventing senile alopecia.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study
research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
research Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia
PRP therapy increases hair density for androgenetic alopecia.
research Regulation of hair follicle development by exosomes derived from dermal papilla cells
Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
research Aging in hair follicle stem cells and niche microenvironment
Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
research Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies
Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.
research Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction
Stress can cause early aging in certain skin cells, leading to problems with hair growth.
research Androgenetic alopecia: a review
Male pattern baldness involves genetics, hormones, and needs better treatments.
research Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia
New genes found linked to balding, may help develop future treatments.
research Dermal sheath cells contribute to postnatal hair follicle growth and cycling
Skin sheath cells help in hair growth and renewal after birth.
research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
research Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia
Oxidative stress affects hair loss in men with androgenetic alopecia.
research Age-related hair changes in men: Mechanisms and management of alopecia and graying
Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.
research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells
Arctiin helps protect hair cells from damage and death caused by oxidative stress.
research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
research Neonatal murine skin-derived cells transplanted using a mini-chamber model produce robust and normal hair
Transplanted baby mouse skin cells grew normal hair using a new, efficient method.
research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation
UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
research Association between Smoking and Hair Loss: Another Opportunity for Health Education against Smoking?
Smoking may contribute to hair loss in men.
Related
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.