Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies
June 2017
in “Experimental Dermatology”
TLDR Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.
The document from 2017 explores the potential of hair follicle dermal stem cells (hfDSCs) and skin-derived precursor cells (SKPs) in hair follicle regeneration and their use in therapies for hair loss and skin diseases. It highlights the role of hfDSCs in replenishing the dermal papilla (DP) and connective tissue sheath (CTS), which are crucial for hair growth, and suggests that these cells could be used to repopulate the DP to treat hair loss. The authors also discuss the importance of the transcription factor Sox2 in maintaining hfDSC plasticity and call for a redefinition of SKPs based on functional characteristics. They conclude that hfDSCs and SKPs hold promise for restorative therapies, particularly hfDSCs for their unique ability to reconstitute HF mesenchyme and induce hair growth, but emphasize the need for further research to advance clinical applications.
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Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
research Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells
Dermal papilla cells help wounds heal better and can potentially grow new hair.
research Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
Growing human skin cells in a 3D environment can stimulate new hair growth.
research Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline
More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo
Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.
research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
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