Aging in hair follicle stem cells and niche microenvironment
June 2017
in “The Journal of Dermatology”
TLDR Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
The document from 2017 reviews the impact of aging on hair follicle stem cells (HFSCs) and their microenvironment, which are essential for hair growth and pigmentation. It discusses the role of HFSCs in hair regeneration, the signaling pathways that regulate their maintenance and activation, and the importance of circadian rhythms in their function. The review also addresses the prevalence of androgenetic alopecia in men, the mechanisms behind hair graying, and the distinct processes involved in different types of hair loss. It suggests that aging in HFSCs and melanocyte stem cells (MSCs) leads to hair graying, thinning, and loss, and that targeting the stem cell niche environment could offer a strategy for rejuvenating HFSCs. The document underscores the need for further research to understand hair aging and identify potential therapeutic targets.
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