Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
January 2013
in “Journal of Investigative Dermatology”
TLDR Wnt ligands are crucial for hair growth and repair.
The study from January 1, 2013, demonstrated that epithelial Wnt ligands are essential for adult hair follicle growth and regeneration. By genetically deleting the Wntless (Wls) gene in mice, which is necessary for Wnt ligand secretion, researchers observed a significant arrest in the hair cycle, specifically in the transition to the anagen phase. The absence of Wls led to decreased Wnt/ß-catenin signaling and reduced proliferation of hair follicle stem cells, although stem cell markers were maintained. The study also found that Wnt ligands are critical for wound-induced hair formation, suggesting their importance in hair follicle regeneration. These findings imply that Wnt ligand secretion by the hair follicle epithelium could be a potential target for treating hair loss disorders like alopecia.
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Cited in this study
research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
research Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells
β-catenin is essential for stem cell activation and proliferation in hair follicles.
research Molecular principles of hair follicle induction and morphogenesis
Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
research Molecular Mechanisms Regulating Hair Follicle Development
Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration
S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
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research 693 Dermal papilla-derived Wnt ligands are required for adult hair follicle growth
Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
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research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.
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