Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

    Shigeki Inui, Yoshimitsu Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, Satoshi Itami
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    TLDR TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
    This study investigated the pathomechanism of androgenetic alopecia (AGA) by establishing an in vitro coculture model of human dermal papilla cells (DPCs) from AGA and keratinocytes (KCs). The study found that androgen-inducible TGF-β1 derived from DPCs mediates hair growth suppression in AGA. The study suggests that targeting TGF-β1 may be a potential therapeutic strategy for androgenetic alopecia.
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