Dermal sheath cells contribute to postnatal hair follicle growth and cycling
May 2016
in “Journal of Dermatological Science”
TLDR Skin sheath cells help in hair growth and renewal after birth.
The document from 7 years ago discussed the role of fibroblasts, specifically dermal papilla (DP) and dermal sheath (DS) cells, and keratinocytes in the production and maintenance of hair follicles. It highlighted that while keratinocytes are the primary constituents of hair follicles that generate the hair structure, the contribution of dermal fibroblasts to hair follicle neogenesis and regeneration is less well defined. The paper noted that DP cells of growing follicles possess hair-inducing ability and interact with keratinocytes to achieve regenerative hair growth. However, attempts to elicit human follicle neogenesis with cultured human DP cells have not been very successful, partly because they lose inductivity during passaging. The document suggested that more research was needed to better understand the role of the mesenchyme in intact follicles, particularly the DS, which had received little attention.
View this study on jdsjournal.com →
Cited in this study
research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
Related
research KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis
KY19382 helps to regrow hair and create new hair follicles.
research Canonical Wnt-10b signaling exert an ability of maintaining mouse dermal papilla cells
Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
research CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth
Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.
research Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth
Activating β-catenin in certain skin cells speeds up hair growth in mice.
research Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin
Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells
Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.