Effect of Clitocybin A on the Proliferation of Dermal Papilla Cells

January 2014 in “ Repositorio Institucional ”

Jung-Il Kang, Kim Min Kyoung, Eun-Sook Yoo, Ick‐Dong Yoo, Hee Kyoung Kang

Clitocybin A dermal papilla cells hair cycle regulation cell-cycle progression cyclin D1 phospho-pRB phospho-CDK2 wnt/β-catenin signaling hair follicle development phospho(ser552)-β-catenin phospho(ser675)-β-catenin phospho(ser9)-GSK3β ERK pathway DPCs Wnt signaling ERK signaling

TLDR Clitocybin A from a mushroom may promote hair growth by increasing cell activity in hair follicles.

The study evaluated the hair growth-promoting effects of Clitocybin A from the mushroom Clitocybe aurantiaca on dermal papilla cells (DPCs), which are crucial in hair cycle regulation. Clitocybin A significantly increased the proliferation of immortalized rat vibrissa DPCs by promoting cell-cycle progression from G0/G1 to S phase and increasing levels of cell cycle proteins like cyclin D1, phospho-pRB, and phospho-CDK2. It activated wnt/β-catenin signaling, crucial for hair follicle development and growth, by increasing phospho(ser552)-β-catenin, phospho(ser675)-β-catenin, and phospho(ser9)-GSK3β. Additionally, Clitocybin A enhanced the activation of the ERK pathway. These findings suggested that Clitocybin A could induce hair growth by promoting DPC proliferation through cell-cycle progression and activation of Wnt/β-catenin signaling and the ERK pathway.

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