Bio‐active designed peptide for hair keratin strengthening

This study explores the development of bioactive tripeptides, particularly palmitoylated versions like pal-KCV, for strengthening hair keratin. Researchers tested 216 tripeptide candidates, focusing on their binding affinity with keratin proteins, and identified optimal sequences that enhance hair strength and resilience. Pal-KCV showed the highest binding energy and significantly improved hair tensile strength and thermal stability, reducing breakage by 48%-52%. The study involved testing on 50 hair strands per group, providing robust evidence for the efficacy of these peptides. The findings suggest potential applications in hair care products, emphasizing the need for further research across diverse conditions.