Baricitinib Safety for Events of Special Interest in Populations at Risk: Analysis from Randomised Trial Data Across Rheumatologic and Dermatologic Indications
February 2023
in “Advances in Therapy”
TLDR Baricitinib, a drug for rheumatoid arthritis, atopic dermatitis, and alopecia areata, is generally safe with low risk of major side effects, even in patients with risk factors. It's also effective in promoting hair regrowth in alopecia areata patients.
The document analyzes the safety of Baricitinib, a medication used for treating rheumatoid arthritis (RA), atopic dermatitis (AD), and alopecia areata (AA). The study pooled data from clinical trials and long-term extensions, involving 7709 patients and up to 9.3 years of exposure. The study found that patients with low risk factors had low incidence rates of major adverse cardiovascular events, malignancies, venous thromboembolism, serious infection, and mortality. Even in patients with risk factors, the incidence rates were low for dermatologic indications. The study concludes that considering individual disease burden, risk factors, and response to treatment is important for making informed decisions for patients treated with Baricitinib. For AA, baricitinib has demonstrated significant hair regrowth in clinical trials.
View this study on link.springer.com →
Cited in this study
research Integrated Safety Analysis of Baricitinib in Adults With Severe Alopecia Areata From Two Randomized Clinical Trials
Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.
research Two Phase 3 Trials of Baricitinib for Alopecia Areata
Baricitinib was effective in treating alopecia areata in two major trials.
research Comorbidities in alopecia areata: A systematic review and meta-analysis
People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.
research Cancer risk by the subtype of alopecia
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