Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis
March 2012
in “Clinical and Experimental Dermatology”
TLDR G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.
This meta-analysis examined the association between androgen receptor gene polymorphisms and androgenetic alopecia (AGA). The study found that the G allele of the AR Stul polymorphism may be a potential risk factor for AGA, especially in white populations. However, the CAG and GGC triplet-repeat polymorphisms of the AR gene did not have any obvious association with risk for AGA. The study suggests that further large studies with adequate methodological quality are necessary to obtain valid results.
View this study on academic.oup.com →
Cited in this study
research Prevalence of androgenetic alopecia in China: a community-based study in six cities
Baldness is more common in Chinese men than women, increasing with age, and is influenced by genetics.
research Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia
AR gene not major factor in female hair loss; different from male hair loss.
research Prevalence and types of androgenetic alopecia in Shanghai, China: a community-based study
Chinese men have lower AGA rates than Caucasians, with type III vertex most common; family history is important.
research EDA2R Is Associated with Androgenetic Alopecia
EDA2R gene linked to hair loss.
research Association of Androgenetic Alopecia With Smoking and Its Prevalence Among Asian Men
Smoking linked to hair loss in Asian men.
research Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia
AR polyglycine repeat doesn't cause baldness.
research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia
Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
research The E211 G>A Androgen Receptor Polymorphism Is Associated with a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia
E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.
research Molecular mechanisms of androgenetic alopecia
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
research The prevalence and types of androgenetic alopecia in Korean men and women
AGA more common in men, Koreans have lower rates and unique patterns.
research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)
Hair loss in women is common, starts in late 20s, and affects 30% of women over 50.