Protective Role of Agomelatine via Modulation of TLR4/NF-κB: NLRP3/IL-1β Signaling Pathways in Testosterone-Induced Benign Prostatic Hyperplasia in Rats

    December 2025 in “ Naunyn-Schmiedeberg s Archives of Pharmacology ”
    Asmaa Mohamed Abdel‐Aziz, Sara M. Ahmed, Walaa Yehia Abdelzaher … Alyaa Abdelfattah Abdelmonaem
    Studysummary In this animal study, AGO (agomelatine) effectively alleviated testosterone-induced benign prostatic hyperplasia in rats by reducing oxidative stress and inflammation, indicating its potential as a therapeutic option for managing BPH through specific signaling pathways.
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    Research cited in this study 4

    1. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    2. Finasteride-Associated Male Infertility Fertility and Sterility · 2010
    3. 5α-Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009
    4. Dihydrotestosterone and the Concept of 5-Alpha-Reductase Inhibition in Human Benign Prostatic Hyperplasia European Urology · 2000