135 citations
,
March 2000 in “Journal of Biological Chemistry”
This review discusses the roles of the Agouti and Agouti-related proteins in pigmentation and energy regulation and reports no new experimental findings.
43 citations
,
May 1999 in “Journal of Biological Chemistry”
This study found that full-length Agouti protein modulates melanocortin receptor signaling through a dual mechanism involving competitive antagonism and receptor down-regulation, whereas the carboxyl-terminal fragment acts solely as a competitive antagonist.
12 citations
,
September 2018 in “International Journal of Cosmetic Science”
This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.
A user stopped taking finasteride 90 days ago but still experiences side effects like reduced sensitivity and erectile issues. They are considering micro-dosing topical finasteride and exploring other treatments like exercise and diet changes, while others suggest checking hormone levels and trying alternatives like RU58841 or dutasteride.
A 20-year-old has been using oral Dutasteride, oral Minoxidil, and a topical mix of Minoxidil and Finasteride for hair loss but hasn't seen significant results. Suggestions include considering a hair transplant, increasing Dutasteride dosage, or trying RU58841.
A user shared their 4-year progress using 1mg daily finasteride for hair loss, noting significant improvement without side effects. They did not use minoxidil tablets due to availability issues but are satisfied with their results.
Minoxidil can cause increased hair shedding initially, which is normal. Finasteride is available in France, but may require a special doctor's note and check-up.