Activin A-induced signalling controls hair follicle neogenesis
January 2017
in “Experimental Dermatology”
TLDR Activin A is important for creating new hair follicles.
In the 2017 study, researchers discovered that activin A plays a crucial role in hair follicle neogenesis. They found that activin A levels were higher in three-dimensional cultured human dermal papilla cells than in two-dimensional cultures. When activin A or its receptor ActvR2B was knocked down, hair follicle formation was severely impaired, indicating the importance of activin A signaling in this process. Additionally, treating mouse epidermal cells with recombinant activin A increased the expression of genes downstream in the Activin pathway, further supporting the significance of activin A in hair follicle development. The study did not mention the number of subjects involved.
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