Treatment of Acne Vulgaris: Everything We Should Know About Isotretinoin

The review paper discusses isotretinoin, a potent systemic therapy for severe acne vulgaris, highlighting its mechanisms, effectiveness, and associated challenges. Isotretinoin reduces sebum production and inflammation but comes with significant side effects, including teratogenic risks, dry skin, depression, liver impairment, and elevated triglycerides. Most side effects resolve post-treatment, and patient awareness, along with systematic monitoring of liver enzymes and lipid profiles, can mitigate risks. Despite its challenges, isotretinoin remains a critical option for treating severe acne when monitored appropriately.