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In this case report, a 30-year-old male with alopecia universalis and autoimmune conditions experienced treatment failure with JAK inhibitors, including ritlecitinib, and developed severe musculoskeletal pain, indicating a potential novel adverse effect that warrants further pharmacovigilance.

In this study, researchers observed that vitamin D deficiency is common among patients with musculoskeletal pain admitted to the hospital, with particularly low levels found in females.

This review discusses the use of platelet-rich plasma for musculoskeletal pain relief and function improvement, but notes the current studies' limitations regarding methods and types of treatment.

This case report highlights the importance of considering SLE in young male patients with unexplained inflammatory musculoskeletal symptoms, as systemic inflammation was identified and symptoms improved with hydroxychloroquine.

This study reviewed isotretinoin's effectiveness in treating moderate to severe acne and discussed the need to balance its robust treatment benefits with careful monitoring due to significant physiological and psychological side effects.