Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

    February 2002 in “ Current Opinion in Cell Biology ”
    Pierre A. Coulombe, M. Bishr Omary
    Studysummary Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.
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    Research cited in this study 16

    1. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    2. Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b The Journal of Cell Biology · 2001
    3. Genes for Intermediate Filament Proteins and the Draft Sequence of the Human Genome Journal of Cell Science · 2001
    4. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    5. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001
    6. A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001
    7. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments ˜The œjournal of cell biology/˜The œJournal of cell biology · 2000
    8. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000
    9. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and Its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000
    10. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
    11. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 ˜The œjournal of cell biology/˜The œJournal of cell biology · 1999
    12. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    13. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    14. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    15. The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs Genomics · 1998
    16. Keratin 17 Mutations Cause Either Steatocystoma Multiplex or Pachyonychia Congenita Type 2 British Journal of Dermatology · 1998