Network Analysis Reveals Potential Mechanisms That Determine the Cellular Identity of Keratinocytes and Corneal Epithelial Cells Through the Hox/Gtl2-Dio3 miRNA Axis

    January 2025 in “ Frontiers in Cell and Developmental Biology ”
    Yanjie Guo, Weini Wu, Haoyu Chen … Xueyi Yang
    Studysummary This study explored the molecular mechanisms determining the identity of keratinocytes and corneal epithelial cells, finding that miRNAs from the Gtl2-Dio3 region, which regulate key signaling pathways, play a significant role in cell identity through the Hox/Gtl2-Dio3 miRNA axis.
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    Research cited in this study 3

    1. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    2. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    3. Transdifferentiation of Corneal Epithelium Into Epidermis Occurs by Means of a Multistep Process Triggered by Dermal Developmental Signals Proceedings of the National Academy of Sciences · 2005