Immortalized Human Hair Follicle-Derived Mesenchymal-Like Stromal Cells for Long-Term Production of Scalable Immunomodulatory and Regenerative Secretome

This review discusses the role of dermal papilla cells in hair follicle formation and their potential use in cell therapy for hair loss, but reports no new research findings.

This study found that hypoxia-preconditioned HF-MSC-derived exosomes improved therapeutic outcomes in models of ulcerative colitis, potentially through miR-214-3p-mediated pathways affecting mitochondrial function and inflammatory responses.

This study found that medium/large extracellular vesicles derived from hair follicle and adipose tissue mesenchymal stromal cells both demonstrated significant neuroprotective and anti-inflammatory effects in cell cultures, highlighting their potential use as biopharmaceuticals for treating neurodegenerative diseases.

This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.

In this study, hair follicle-derived mesenchymal stromal cells showed potential for immunomodulation, with equivalent or superior responses compared to those from adipose tissue, suggesting a promising alternative cell source.

This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.

This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.