Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice

    April 2013 in “ PLOS ONE ”
    Eddy Wang, Katy Chong, Man Yu … Kevin J. McElwee
    Studysummary This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.
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    Research cited in this study 11

    1. The Genetics of Alopecia Areata: What's New and How Will It Help Our Patients? Dermatologic therapy · 2011
    2. Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It? Dermatologic therapy · 2011
    3. Nonsegmental Vitiligo and Autoimmune Mechanism Dermatology Research and Practice · 2011
    4. An Implication for Post-Transcriptional Control: Reciprocal Changes of Melanocortin Receptor Type 2 mRNA and Protein Expression in Alopecia Areata Medical Hypotheses · 2010
    5. Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study Journal of The American Academy of Dermatology · 2010
    6. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    7. Hypertension and Aldosterone Levels in Women with Early-Onset Androgenetic Alopecia British Journal of Dermatology · 2009
    8. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    9. Is Baldness Bad for the Heart? Dermatology · 2005
    10. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    11. Alopecia Areata in Korea (1982–1994) The Journal of Dermatology · 1995