Development of Pluripotent Stem Cell-Derived Epidermal Organoids That Generate Effective Extracellular Vesicles in Skin Regeneration

February 2024 in “ Biomaterials ”

Sojung Kwak, Cho Lok Song, Jinhyuk Lee, Sung‐Yeon Kim, Seungyoon Nam, Young‐Jun Park, Jungwoon Lee

pluripotent stem cells epidermal organoids induced pluripotent stem cells iPSCs extracellular vesicles VEGF miRNAs hair follicle stem cells angiogenesis regenerative medicine stem cells EpiOs iEpiOs growth factor vascular endothelial growth factor microRNAs

Studysummary In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

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