The Mouse Frizzy (Fr) And Rat ‘Hairless’ (FrCR) Mutations Are Natural Variants Of Protease Serine S1 Family Member 8 (Prss8)

    February 2010 in “ Experimental Dermatology ”
    Damek V. Spacek, Amarilis F. Perez, Katelynn Ferranti … Thomas R. King
    Studysummary This study concluded that the frizzy mutation in mice is linked to a T to A transversion in Prss8 and is orthologous to the 'hairless' mutation in rats.
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    Research cited in this study 10

    1. Autosomal Recessive Ichthyosis With Hypotrichosis Syndrome: Further Delineation Of The Phenotype Clinical Genetics · 2008
    2. Autosomal Ichthyosis With Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007
    3. Premature Termination of Hair Follicle Morphogenesis and Accelerated Hair Follicle Cycling in Iasi Congenital Atrichia (fzica) Mice Points to Fuzzy as a Key Element of Hair Cycle Control Experimental dermatology · 2005
    4. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    5. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002
    6. Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis Oncogene · 2002
    7. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables Experimental dermatology · 2001
    8. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000
    9. The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype Developmental Dynamics · 1999
    10. The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen Journal of Investigative Dermatology · 1999