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Research

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research The mouse frizzy (fr) and rat ‘hairless’ (fr^CR) mutations are natural variants of protease serine S1 family member 8 (Prss8)

28 citations , February 2010 in “Experimental Dermatology”

This study concluded that the frizzy mutation in mice is linked to a T to A transversion in Prss8 and is orthologous to the 'hairless' mutation in rats.

research A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis

21 citations , June 2009 in “Mammalian genome”

This study describes a mouse model for Marie Unna Hereditary Hypotrichosis, identifying mutations in the hairless gene that result in sparse or absent hair and cyst-like hair follicles.

research The hairless (hr) gene is involved in the congential hypotrichosis of Valle del Belice sheep

January 2002 in “Agritrop (Cirad)”

This study found that mutations in exon 3 of the hr gene are strongly associated with congenital hypotrichosis in Valle del Belice sheep, suggesting a potential genetic link to the disorder.

research The retarded hair growth ( rhg ) mutation in mice is an allele of ornithine aminotransferase ( Oat )

9 citations , January 2014 in “Molecular Genetics and Metabolism Reports”

This study discovered that a specific G to C mutation in the ornithine aminotransferase gene is linked to the retarded hair growth phenotype in mice and may serve as a model for human gyrate atrophy.

research A Spontaneous Fatp4/Scl27a4 Splice Site Mutation in a New Murine Model for Congenital Ichthyosis

13 citations , November 2012 in “PLoS ONE”

This study identified a novel recessive mutation in mice causing lethal congenital lamellar ichthyosis, with skin and hair follicle alterations similar to human congenital ichthyoses, linked to a specific genetic defect affecting Fatp4.

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Community Join

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community Can't get dutasteride from dermatologist office

5 upvotes 3 days ago

The user has been using oral minoxidil and finasteride for hair loss with no side effects and wants to try dutasteride but was denied by a dermatologist's office. They suspect the office was promoting Rogaine instead, which is more expensive than their current treatment.

community Don’t wait around, take action now.

452 upvotes 1 month ago

The user shared their positive experience with hair regrowth using minoxidil, finasteride, and ketoconazole shampoo, alongside lifestyle changes like a healthy diet and exercise. They emphasized the importance of starting treatment early and staying consistent.

community Don’t neglect your scalp health guys

112 upvotes 3 months ago

Improving scalp health can significantly impact hair loss treatment effectiveness. Using ketoconazole shampoo to reduce inflammation and dandruff can enhance the results of treatments like Dutasteride and Minoxidil.

community Doesn't feel like there's any good options (Rant)

in Chat 17 upvotes 4 months ago

An 18-year-old is experiencing significant hair loss and is concerned about treatment options, including finasteride, minoxidil, and dutasteride, due to potential side effects and costs. They are also taking vitamins for deficiencies and considering alternatives like hair transplants or embracing the bald look.

community Don't be inconsistent with Minoxidil, you will lose progress fast. My new plan for future.

161 upvotes 5 months ago

Inconsistent minoxidil use led to hair loss, prompting a plan to resume consistent application with derma stamping, red light therapy, and DHT blockers like clascoterone or RU58841. The user avoids finasteride and dutasteride due to past side effects.

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Learn

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learn Dutasteride

Dutasteride: Why don't some doctors prescribe it if it's stronger than finasteride? Dutasteride is off-label for hair loss in the US, the EU and the UK, stays in the body for months after the last dose, and has less long-term data in hair loss than finasteride. Its US label also states that sexual side effects may persist after stopping, with dutasteride's role unknown, and in 2026 the UK regulator added a precautionary warning about depression and suicidal thoughts.

learn Scalp Micropigmentation

Why can't I see my scalp micropigmentation after a week? Providers say fading after the first session is normal and that later sessions add density.

learn Hair Transplant

What happens if I don't have enough donor hair for a hair transplant? Body hair or beard hair can be used if scalp donor hair is insufficient.

learn Redensyl

What does Redensyl do that other natural ingredients don't? Redensyl's maker says it acts on follicle stem cells; the only human data are small supplier studies, not independent trials.

learn Baricitinib

Baricitinib: Can I use it even if I don’t have a medical diagnosis but I have patchy hair loss? Baricitinib is approved only for adults with a diagnosis of severe alopecia areata and carries an FDA boxed warning. Patchy hair loss has many causes, so doctors confirm the diagnosis before prescribing it.

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Clinics

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Experts

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Hair Transplant Surgeon
Dr. Dow Stough, MD

Dr. Dow Stough, MD