Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis

January 2011 in “ EXPERIMENTAL ANIMALS ”

Takashi Kuramoto, Mitsuru Kuwamura, Fumi Tagami, Tomoji Mashimo, Masato Nose, Tadao Serikawa

TLDR A new rat strain with a specific gene mutation causes hair loss and kidney issues.

The study characterized a novel mutant rat strain, F344-Hrkrh, created through ENU mutagenesis, which exhibited congenital hair loss and focal glomerulosclerosis (FGS) due to a nonsense mutation (S413X) in the Hr gene. This mutation led to a truncated HR protein, resulting in premature hair follicle cycling and cystic hair follicles. By 8 weeks, the rats showed hair loss, and by 4 months, they developed wrinkled skin and long curved nails. Histopathological analysis of 40-week-old rats revealed significant kidney lesions and proteinuria. The F344-Hrkrh strain was suggested as a model for studying skin diseases and FGS pathogenesis, as it did not display autoimmune symptoms seen in other models with similar mutations.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

59 citations , September 2008 in “Experimental dermatology”

Both mouse and rat models are effective for testing alopecia areata treatments.

research The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes

35 citations , April 2008 in “Journal of Biological Chemistry”

Hirosaki hairless rats lack hair due to missing DNA with key keratin genes.

Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

Related Research

1 / 1 results

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis

Research cited in this study

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

research The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

research Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat

research Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

research The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation

research Alopecia Universalis Associated with a Mutation in the Human hairless Gene

Related Research

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis