So Much More Than Just Structural Support: Laminin-332 and Its Multifaceted Functions in Skin Homeostasis and Disease

    June 2026 in “ Experimental Dermatology ”
    Piotr Parzymies
    Studysummary This review explores the roles of laminin-332 in skin function, highlighting its involvement in epidermal cohesion, stem cell maintenance, wound healing, and potential in genetic therapies for junctional epidermolysis bullosa.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. Hemidesmosomes And Notch Signaling Regulate Epidermal Differentiation Via Delamination Development · 2026
    2. Keratinocyte Integrin α3β1 Induces Expression of the Macrophage Stimulating Factor, CSF-1, Through a YAP/TEAD-Dependent Mechanism. Matrix Biology · 2024
    3. Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    4. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin Journal of Investigative Dermatology · 2019
    5. Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne Nature Communications · 2018
    6. Re-Investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis? Journal of histochemistry and cytochemistry/˜The œjournal of histochemistry and cytochemistry · 2018
    7. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018
    8. Laminin α5 in the Keratinocyte Basement Membrane Is Required for Epidermal–Dermal Intercommunication Matrix Biology · 2016
    9. Reduced Cell Cohesiveness of Outgrowths from Eccrine Sweat Glands Delays Wound Closure in Elderly Skin Aging Cell · 2016
    10. Spatial And Temporal Control Of Laminin-511 And -332 Expressions During Catagen Journal of Dermatological Science · 2010