Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

August 2017 in “ Nature cell biology ”

Aimee Flores, John C. Schell, Abigail S. Krall, David Jelínek, Matilde Miranda, Melina Grigorian, Daniel Braas, Andrew C. White, Jessica L. Zhou, Nicholas Graham, Thomas G. Graeber, Pankaj Seth, Denis Evseenko, Hilary A. Coller, Jared Rutter, Heather R. Christofk, William E. Lowry

lactate dehydrogenase LDH hair follicle stem cells HFSCs glycolytic metabolism Ldha gene lactate production Mpc1 gene mitochondrial pyruvate carrier hair cycle progression regenerative medicine lactate hair growth

Studysummary This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

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