Pten Loss In Lgr5+ Hair Follicle Stem Cells Promotes SCC Development

    January 2019 in “ Theranostics ”
    Haiyan Chen, Xusheng Wang, Yu Chen … Yaojiong Wu
    Studysummary This study found that loss of the Pten gene in Lgr5+ hair follicle stem cells promoted squamous cell carcinoma formation through the Akt/β-catenin signaling pathway.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on thno.org →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    2. Lgr6+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors Oncotarget · 2016
    3. Lgr5+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors Oncotarget · 2016
    4. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    5. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    6. Progeny of Lgr5-Expressing Hair Follicle Stem Cell Contributes to Papillomavirus-Induced Tumor Development in Epidermis Oncogene · 2012
    7. The Human Promyelocytic Leukemia Protein Is a Tumor Suppressor for Murine Skin Carcinogenesis Molecular Carcinogenesis · 2008
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004