Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

    May 1996 in “ Journal of Investigative Dermatology ”
    Alejandro Peralta Soler, G Gilliard, Louis C. Megosh, Thomas G. O’Brien
    Studysummary This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.
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    Research cited in this study 4

    1. A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice Proceedings of the National Academy of Sciences · 1995
    2. Ornithine Decarboxylase Expression in Cutaneous Papillomas in SENCAR Mice Is Associated with Altered Expression of Keratins 1 and 10 PubMed · 1994
    3. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    4. The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins Differentiation · 1986

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