Investigating the Genetic Association of Selected Candidate Loci with Alopecia Areata Susceptibility in Jordanian Patients

February 2025 in “ Medicina ”

Laith N. AL‐Eitan, Maryam Alasmar, Hanan A. Aljamal, Ahmad Mihyar, Mansour A. Alghamdi

alopecia areata genetic association candidate loci Sequenom MassARRAY system

Studysummary This study examined genetic risk factors for alopecia areata in the Jordanian population but found no significant association between the 21 targeted risk loci and the condition, emphasizing variability in genetic predisposition across ethnic groups and potential non-genetic triggers.

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This study examined the genetic association of 21 candidate loci with alopecia areata (AA) susceptibility in a Jordanian cohort of 152 patients and 150 controls. Using genetic sequencing, no significant association was found between the selected SNPs and AA in this population. The findings underscore the genetic variability of AA across different ethnic groups and suggest that environmental and psychological factors may also contribute to the disease's etiology. The study highlights the complexity of AA's genetic basis and the need for further research to identify genetic factors influencing AA.

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research Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients

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research A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States

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This study suggests that the prevalence of alopecia areata in the US remains similar to high estimates from the 1970s, with significant implications for quality of life.

research Candidate Gene Analysis of Alopecia Areata in Jordanian Population of Arab Descent: A Case-Control Study

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This study identified a significant genetic association between the TNFα gene and alopecia areata susceptibility in the Jordanian Arab population.

research The Association Between rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata

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research The Role of Micronutrients in Alopecia Areata: A Review

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This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.

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research Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata

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research Epidemiology and Burden of Alopecia Areata: A Systematic Review

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This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.

research The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments

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This review summarizes the current genetic research on alopecia areata, including potential new therapeutic strategies, but reports no new clinical findings.

research Overview of Alopecia Areata

110 citations , December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This article reviews current understanding of alopecia areata, its genetic and immune factors, and discusses ongoing research and treatment development, without presenting new experimental results.

research Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis

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research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

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research Autoimmunity: Alopecia Areata

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This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.

research Clinical Presentations of Alopecia Areata

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This review discusses the clinical presentations of alopecia areata, introduces guidelines for treatment studies, and explores potential changes in cutaneous innervation, but reports no new clinical results.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

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This study found that androgenetic alopecia causes significant psychological distress, particularly in women, who exhibit a more negative body image and less adaptive functioning compared to controls.