Multiple Basal Cell Carcinomas in a Patient with Myotonic Dystrophy Type 1

March 2019 in “ Case Reports ”

Jessica Feng, Avery LaChance, David A. Sinclair, Maryam M. Asgari

basal cell carcinoma squamous cell carcinoma myotonic dystrophy type 1 DMPK gene DNA repair cell death sun protection skin cancer surveillance BCC SCC DM1

Studysummary This report highlights a case of possible association between myotonic dystrophy type 1 and basal cell carcinoma, urging clinicians to consider this link despite negative genetic testing for known hereditary BCC syndromes.

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Research cited in this study

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research Cutaneous Neoplasms in Myotonic Dystrophy Type 1

10 citations , January 2016 in “Dermatology”

This study found that patients with myotonic dystrophy type 1 developed basal cell carcinomas at a younger age than the general population, suggesting a possible predisposition in this group.

research Dysplastic Nevi, Cutaneous Melanoma, and Other Skin Neoplasms in Patients with Myotonic Dystrophy Type 1: A Cross-Sectional Study

23 citations , January 2015 in “Journal of The American Academy of Dermatology”

This study found that patients with myotonic dystrophy type 1 had higher numbers of nevi, dysplastic nevi, melanomas, and pilomatrixomas compared to age- and sex-matched controls.

research Multiple Pigmented Basal Cell Carcinomas on the Scalp in Myotonic Dystrophy Curschmann-Steinert

18 citations , February 2001 in “Der Hautarzt”

This case study of a 50-year-old woman with myotonic dystrophy and multiple basal cell carcinomas suggests there could be a genetic predisposition for certain cutaneous tumors in such patients.