N,N-Dimethylglycine Sodium Salt Prevents Human Dermal Papilla Senescence and Promotes Hair Growth in Patients With Pattern Hair Loss

    June 2026 in “ Journal of Dermatological Science ”
    Johanna Mihály, A. Lendvai, Gabriella Béke … Tamás Bı́ró
    Studysummary This study found that a topical formulation containing DMG-Na significantly improved hair loss parameters in people experiencing hair loss, suggesting its potential effectiveness for such conditions.
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    Research cited in this study 19

    1. A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (DMG-Na) and Caffeine: Efficacy of a 24-Week, Double-Blind, Randomized, Placebo-Controlled Trial Journal of Cosmetic Dermatology · 2025
    2. Frontiers in the Physiology of Male Pattern Androgenetic Alopecia: Beyond the Androgen Horizon Physiological Reviews · 2025
    3. Topically Applied N,N-Dimethylglycine Sodium Salt Enhances Human Skin Blood Flow by Inducing Endothelial Nitric Oxide Release ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2024
    4. Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2024
    5. N,N-Dimethylglycine Sodium Salt Exerts Anti-Inflammatory Effects in Dermatitis Models and Activates Human Epidermal Keratinocytes International Journal of Molecular Sciences · 2023
    6. Nitric Oxide Signal Transduction and Its Role in Skin Sensitization Biomolecules & therapeutics · 2023
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    19. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997