Maternal Subclinical and Clinical Hypothyroidism Effects on Rat Offspring: A Story of the Skin and Its Derivatives

June 2023 in “ Acta veterinaria ”

Tijana Lužajić Božinovski, Jelena Danilović Luković, Anja Nikolić, Anita Radovanović, Danica Marković, Milica Kovačević Filipović, Mirjana Vasić, Ivan Milošević

hypothyroidism subclinical hypothyroidism overt hypothyroidism antithyroid substance epidermal damage hyperkeratosis germinal layer hair follicles morphogenesis

Studysummary This study found that both subclinical and overt maternal hypothyroidism during pregnancy and lactation caused significant damage to the skin development of rat offspring, including pronounced hyperkeratosis and reduced hair follicle formation, with more severe effects observed in overt hypothyroidism.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciendo.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Epidermal Stem Cells in Wound Healing and Regeneration

71 citations , January 2020 in “Stem Cells International”

This review discusses the biological features and clinical applications of epidermal stem cells in wound healing and tissue regeneration, emphasizing the need for further understanding of their mechanisms.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.

research Stem Cells and Their Niches

1549 citations , March 2006 in “Science”

This review discusses the stem cell niche concept in mammalian systems and reports no new clinical results, highlighting recent progress and identifying important unanswered questions.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.