Efficacy and Safety of Low-Dose Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Trial

    January 2025 in “ Annals of Dermatology ”
    Subin Lee, Jung Eun Kim, Bark‐Lynn Lew … Hoon Kang
    Studysummary In this study, 0.2 mg dutasteride significantly improved hair growth in men with androgenetic alopecia compared to placebo over 24 weeks, showing similar efficacy to the higher 0.5 mg dose with a favorable safety profile.
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    Research cited in this study 17

    1. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    2. Long-Term Effectiveness and Safety of Dutasteride Versus Finasteride in Patients With Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study Annals of Dermatology · 2022
    3. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    4. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    5. Diuretics Elsevier eBooks · 2017
    6. Understanding Patient and Physician Perceptions of Male Androgenetic Alopecia Treatments in Asia-Pacific and Latin America Journal of Dermatology · 2017
    7. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    8. Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia Journal of Dermatology · 2016
    9. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    10. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012
    11. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    12. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    13. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    14. Androgenetic Alopecia: Quality of Life and Associated Lifestyle Patterns International Journal of Trichology · 2010
    15. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    16. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    17. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996

    Related research 3

    1. Efficacy And Safety Of Dutasteride In The Treatment Of Alopecia: A Comprehensive Review Expert Opinion on Pharmacotherapy · 2025
    2. Effectiveness and Safety of Oral Dutasteride for Male Androgenetic Alopecia in Real Clinical Practice: A Descriptive Monocentric Study Dermatologic Therapy · 2019
    3. Discovery and Clinical Development of Dutasteride, a Potent Dual 5α-Reductase Inhibitor Current topics in medicinal chemistry · 2006