54 citations
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May 2001 in “Journal of Investigative Dermatology” This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.
2 citations
,
November 2017 in “Histochemistry and Cell Biology” This study observed varying levels of polyamines in different compartments of rat hair follicles, indicating their potential involvement in hair growth, especially in the matrix and inner root sheath layers.
42 citations
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February 1996 in “Journal of Investigative Dermatology” This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.
12 citations
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December 2009 in “Amino Acids” In this study, topical application of α-methylspermidine during the telogen phase in mice induced hair growth by increasing the polyamine pool and mimicking the anagen phase's characteristics.
37 citations
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February 2005 in “Journal of Investigative Dermatology” This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.