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research Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis

10 citations , July 1980 in “British Journal of Dermatology”

This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.

Topical Eflornithine: Efficacy in Reducing Unwanted Facial Hair Growth in Women

research Topical Eflornithine

115 citations , January 2001 in “American journal of clinical dermatology”

This study found that eflornithine 15% cream reduced unwanted facial hair growth more effectively than a placebo in women with hirsutism, but hair growth returned to pretreatment levels within 8 weeks of stopping treatment.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Keratosis follicularis spinulosa decalvans in a family

32 citations , February 2008 in “Journal of the American Academy of Dermatology”

This case report describes a family with autosomal dominant transmission of keratosis follicularis spinulosa decalvans, with observed treatment refractoriness in multiple topical and systemic therapies.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

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Community Join

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community Topical Minxodil stoped working- switching to oral?

1 upvotes 1 week ago

The user experienced reduced effectiveness of topical Minoxidil after three years and is considering switching to oral Minoxidil, while also using finasteride for six months without significant hair regrowth. Suggestions include continuing finasteride for longer, considering oral Minoxidil, or switching to dutasteride for better results.

community Topical Finasteride dose doubts

1 week ago

A user is considering using a topical compound of 0.25% finasteride and 5% minoxidil for hair loss, concerned about side effects experienced with oral finasteride. Other users suggest starting with a lower concentration and possibly diluting the solution to minimize side effects.

community Topical Minoxidil causes this face puffiness?

32 upvotes 1 week ago

A user is concerned about facial puffiness potentially caused by minoxidil, but others suggest it might be due to aging, lighting, or water retention. The user has been using topical minoxidil for 8 months and recently started oral minoxidil, noticing changes in facial appearance.

community Topical finasteride - Can anyone here share their results?

4 upvotes 1 week ago

Topical finasteride combined with oral minoxidil is used by some for hair loss, with mixed results; some users report success while others find it difficult to apply. Alternatives like oral finasteride and microneedling are also considered, with some users experiencing hair stabilization and new growth.

community TOPICAL dut vs. ORAL fin: more effective?

4 upvotes 2 weeks ago

Switching from oral finasteride to topical dutasteride for hair loss, with mixed experiences reported; some users found oral treatments more effective. Combining treatments like dutasteride and minoxidil was also suggested for better results.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin primarily hydrates hair but does not increase thickness or follicle function.

learn L-cysteine

Can topical products with L-cysteine repair damaged hair or prevent breakage? Topical L-cysteine cannot effectively repair damaged hair or prevent breakage.

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