Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

    September 2018 in “ Journal of Investigative Dermatology ”
    Ana Korosec, Sophie Frech, Bernhard Geßlbauer … Beate M. Lichtenberger
    Studysummary This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.
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    Research cited in this study 9

    1. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    2. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    3. In Vitro Models to Study Hair Follicle Generation Elsevier eBooks · 2017
    4. Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins British journal of dermatology/British journal of dermatology, Supplement · 2016
    5. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    6. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    7. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    8. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013