Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss

May 2017 in “ Nature Cell Biology ”

Joerg D. Hoeck, Brian Biehs, Antonina V. Kurtova, Noelyn M. Kljavin, Felipe de Sousa e Melo, Bruno Alicke, Hartmut Koeppen, Zora Modrušan, Robert Piskol, Frédéric J. de Sauvage

Lgr5+ stem cells CD34+ stem cells hair follicles Wnt signaling hair regeneration inflammatory response hair germ stem cells hair growth inflammation Wnt pathway

Studysummary Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

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research Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells

142 citations , February 2016 in “Science”

This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.

research Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice

321 citations , March 2015 in “Nature”

This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.

research Stem Cell Dynamics in the Hair Follicle Niche

135 citations , December 2013 in “Seminars in Cell & Developmental Biology”

This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.

research Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate

394 citations , October 2013 in “Nature”

research Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation

176 citations , January 2013 in “Proceedings of the National Academy of Sciences”

This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.

research The Extent of the Uptake of Plasmid Into the Skin Determines the Immune Responses Induced by a DNA Vaccine Applied Topically Onto the Skin

11 citations , January 2011 in “Journal of Pharmacy and Pharmacology”

This study found that inducing hair follicles into the anagen stage by plucking significantly enhances antibody responses in mice after topical DNA vaccine application, compared to retinoic acid or TPA treatments.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells

415 citations , January 2008 in “Cell”

NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

This study found that active BMP signaling prevents epithelial stem cell activation and expansion in hair follicles, while its inhibition leads to HF stem/progenitor cell overproduction and matricomas.